In a fast-paced immigrant community where dreams are often lost to economic survival, two young Chicanas contemplate life when they stir unexpected desires in each other.

Mosquita y Mari is a coming of age story that focuses on a tender friendship between two young Chicanas. Yolanda and Mari are growing up in Huntington Park, Los Angeles and have only known loyalty to one thing: family. Growing up in immigrant households, both girls are expected to prioritize the well-being of their families. Yolanda, an only child, delivers straight A's and the hope of the American Dream while Mari, the eldest, shares economic responsibilities with her undocumented family who scrambles to make ends meet.

When Mari moves in across the street from Yolanda, they maintain their usual life routine, until an incident at school thrusts them into a friendship and into unknown territory. As their friendship grows, a yearning to explore their strange yet beautiful connection surfaces. Lost in their private world of unspoken affection, lingering gazes, and heart-felt confessions of uncertain futures, Yolanda's grades begin to slip while Mari's focus drifts away from her duties at a new job. Mounting pressures at home collide with their new-found connection, forcing them to choose between their obligations to others and staying true to themselves.